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Water is fast becoming an economically scarce resource in many areas of the world, including Eswatini, especially in arid and semi-arid regions. A study to test the response of lettuce (Lactuca sativa L.) to deficit irrigation was conducted in a field plot experiment at the Faculty of Agriculture at the Luyengo Campus of the University of Eswatini. The treatments were laid in a randomized block design. The experiment consisted of four treatments, each replicated three times. Treatment 1 (T1) was irrigated daily, treatment 2 (T2) irrigated after 2 days, treatment 3 (T3) irrigated after 3 days and treatment 4 (T4) irrigated after 4 days. A total of 30 lettuce plants were planted in each treatment. The lettuce was grown for a period of four weeks and then harvested whole. Yield parameters measured included the number of leaves, the plant height (cm), leaf area index (LAI), and the fresh and dry head mass (grams). Significant differences (P < 0.01) between treatments T3 and T4 were obtained for fresh and dry lettuce head mass. The highest water use efficiency and crop water productivity were obtained in treatment T3. It was concluded that irrigating lettuce every three days was the best option for the area under the conditions of the experiment.
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